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ATTENUATED VACCINE

Definition

(1) A vaccine containing live pathogens whose virulence for a given host species has been reduced or abolished by attenuation. (2) A reduction in the virulence of a pathogen under natural conditions. (3) Any procedure in which the virulence of a given (live) pathogen for a particular host species is reduced or abolished without altering its immunogenicity; attenuation may be achieved by serial passage through an organism, and may be used to prepare vaccines.

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